Effects of lithium on cognitive performance: a meta-analysis wingo ap, wingo ts, harvey pd, baldessarini rj crd summary this review found lithium carbonate had mild negative effects on cognitive performance in immediate verbal learning. Lithium administration has been associated with fluency decrease memory and verbal learning impairments and decreased motor performance, but the neurocognitive adverse effects of lithium are reversible (vasile et al, 2011) the other hand, anticonvulsants are a diverse group of drugs with different effects on cognitive functions. During the two weeks following tbi, the researchers examined the effects of daily lithium treatment on motor and cognitive function, cell loss, and the level of snare proteins some of the rats were also evaluated for spatial memory retention, the part of the memory that records information about one's environment and spatial orientation.
This review found lithium carbonate had mild negative effects on cognitive performance in immediate verbal learning and memory and creativity some methodological flaws and the lack of information about the quality of the included. To test the impact on cognitive performance of serum and brain lithium levels, two multiple regression models were constructed using fas, animals, trails a, wcst perseverative and nonperseverative errors as factors and brain or serum lithium levels as dependent variables.
As its cognitive effects are mixed and not well-known, we assessed reported effects of lithium on cognitive performance medline, psycinfo, and embase databases (1950 to december 2008) were queried with the keywords lithium, cognit, neurocognit, neuropsych, psycholog, attention, concentration, processing speed, memory, executive, and learning. Selective effect of lithium on cognitive performance in man pw glue ~, dj nutt ~, pj cowen 3, and d broadbent 2 the effects of lithium on psychomotor perfor- mance were examined in six healthy male volunteers (aged testing was carried out on a research machines 380z. Despite methodological flaws, poor replicability and the subtle cognitive effects of lithium, five consistent findings emerged from the review impairment on tasks of psychomotor speed, impaired functioning in the majority of studies examining verbal memory, no impairment on tasks of visuo-spatial constructional ability or attention/ concentration, and no negative cumulative effect.
Lithium neurotoxicity, including adverse effects on memory and speed of cognitive and psychomotor performance, 6 may be of particular concern in an older individual with bd as evidence suggests increased cognitive deficits in older compared with younger bd patients 7,8. To assess the effects of lithium on cognitive performance in the treatment of recurrent affective disorders searching medline, embase and psycinfo were searched from inception to december 2008 for relevant english-language studies search terms were reported.
Selective effect of lithium on cognitive performance in man pw glue ~, dj nutt ~, pj cowen 3, and d broadbent 2 testing was carried out on a research machines 380z effect of lithium on semantic processing test raw and change scores (baseline test reaction time -. However, controversy remains regarding these effects although some studies reported cognitive deficits in attention and memory within 14 days of the beginning of lithium treatment, others failed to detect any short-term impact of lithium treatment on cognitive performance ( calil et al, 1990 pachet and wisniewski, 2003.
In general, the studies about the differences in cognitive performance between bd patients treated with lithium or anticonvulsants support the claim that prolonged anticonvulsant, antidepressant, or antipsychotic treatment is associated with a greater risk of dementia than the general population, in contrast to patients treated with lithium. Adverse cognitive effects associated with lithium are often implicated as contributing to vocational and social impairment, as well as medication noncompliance as impaired cognitive functioning caused by lithium has clear clinical implications, it is important to determine whether evidence for or. Lithium’s additional specific neuroprotective effects might compensate for cognitive functioning impairment due to the illness’s neurodegenerative or toxic effects until brain areas are on the verge of substantial damage (and dementia.